Invitrogen™ MTM1 Polyclonal Antibody

Catalog No.	Quantity
PIPA5116357	400 μL

Catalog No. PIPA5116357 Supplier Invitrogen™ Supplier No. PA5116357

Description

Rabbit Polyclonal Antibody

MTM1 Polyclonal Antibody for Western Blot

Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.

Specifications

• Antigen: MTM1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: MTM1
• Gene Accession No.: 0
• Gene Alias: AF073996; CG2; CNM; fb19c01; hypothetical protein LOC560881; im:6903724; mKIAA4176; Mtm; MTM1; MTMX; myotubularin; myotubularin 1; Myotubularin-like protein; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase; wu:fb19c01; X-linked myotubular myopathy gene 1; XLMTM; zgc:123266
• Gene Symbols: MTM1
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide between 451-485 amino acids from the region of DANRE mtm1.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 400 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 560881
• Target Species: Zebrafish
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG