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Invitrogen™ mTOR Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA1518
Description
3-8% Tris-Acetate Gel is recommended for Western blot. PA1-518 detects a predominant band at ~290kD corresponding to mTOR. Other lower MW nonspecific bands of unknown identity were also detected at ~65kD and ~35kD in some cell lysates.
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.
Specifications
mTOR | |
Polyclonal | |
Unconjugated | |
MTOR | |
2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; FKBP12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; flat; FRAP; FRAP1; FRAP2; Mammalian target of rapamycin; mechanistic target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); mechanistic target of rapamycin kinase; Mtor; m-TOR; mTORC1; Raft1; Rapamycin and FKBP12 target 1; rapamycin and FKBP12 target-1 protein; rapamycin associated protein FRAP2; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR; SKS | |
Rabbit | |
Protein G | |
RUO | |
2475, 56717, 56718 | |
-20°C | |
Liquid |
Immunoprecipitation, Western Blot, Immunocytochemistry | |
1 mg/mL | |
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide | |
P42345, P42346, Q9JLN9 | |
MTOR | |
Immunogen corresponds to amino acids 1223-1290 of human mTOR. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Monkey | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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