Invitrogen™ MUNC18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA1742

Catalog No. PA1742

Description

PA1-742 detects Munc-18 from human, rat and mouse tissues. PA1-742 has been successfully used in Western blot, immunohistochemistry, and immunoprecipitation procedures. By Western blot, this antibody detects an ~67 kDa protein representing Munc-18 from rat and mouse whole brain extract. PA1-742 immunizing peptide corresponds to amino acid residues 58-70 from human Munc-18. This sequence is completely conserved between human, mouse, rat, bovine, and canine Munc-18. PA1-742 immunizing peptide (Cat. # PEP-067) is available for use in neutralization and control experiments.

This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

Specifications

• Antigen: MUNC18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Stxbp1
• Gene Alias: AI317162; AI326233; ANC18HA; EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; MMS10-G; Ms10g; MUNC18-1; Munc-18a; munc-18c; neuronal SEC1; NSEC1; n-sec1; NSEC1A; p67; Protein unc-18 homolog 1; protein unc-18 homolog A; rbSec1; Rb-sec1; rbSec1A; rbSec1B; rop; RP11-56D16.3; Sec1; Stxbp1; Sxtbp1; syntaxin binding protein 1; syntaxin-binding protein 1; UNC18; UNC-18 homolog; unc-18-1; Unc18-1; UNC18A; unc-18A; Unc18h
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20910, 25558, 6812
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: O08599, P61764, P61765
• Gene Symbols: Stxbp1
• Immunogen: Synthetic Peptide: V(58) E D I N K R R E P I P S(70).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG