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Invitrogen™ MUTYH Polyclonal Antibody
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Catalog No. 01676626
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100 μg
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Catalog No. Quantity
01-676-626 100 μg
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Catalog No. 01-676-626 Supplier Invitrogen™ Supplier No. PA141003
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Description

Rabbit Polyclonal Antibody

Suggested positive control: Hela whole cell extract.

MYH (mutY homolog (E. coli )) is a DNA glycosylase mismatch repair enzyme that in conjunction with mutM (OGG1), cleaves adenine residues paired with either oxidized (8-hydroxyguanines) or non-modified guanines in order to correct A/G and A/C mismatches. Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair. MYH is crucial for the avoidance of mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing levels of MYH in A549 cells exposed to oxygen and infrared radiation leads to improvements in cell survival. Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons where mitochondrial genomes exposed to reactive oxygen species (ROS) that damage DNA must maintain integrity over the entire mammalian life span.
TRUSTED_SUSTAINABILITY

Specifications

Antigen MUTYH
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA and 0.02% sodium azide
Gene MUTYH
Gene Accession No. Q8R5G2, Q99P21, Q9UIF7
Gene Alias 5730495A01Rik; A/G-specific adenine DNA glycosylase; adenine DNA glycosylase; adenine-DNA glycosylase; hMYH; MGC4416; mMYH; mutY DNA glycosylase; mutY homolog; mutY homolog (E. coli); mutY homolog alpha; Mutyh; Mutyha; Mutyhalpha; Mutyhb; Mutyhbeta; Mutyhc; mutY-like protein; Myh; OTTHUMP00000009098; OTTHUMP00000009102; rMYH; RP4-534D1.2; the full-length form type A, 5' region
Gene Symbols MUTYH
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 531-546 of human MYH.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 170841, 4595, 70603
Target Species Human, Mouse, Rat, Bacteria
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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