Invitrogen™ MVP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA522296

Catalog No. PIPA522296

Description

Recommended positive controls: HeLa, Molt-4, Neuro2A, GL261, C8D30, BCL-1, Raw264.7. Predicted reactivity: Mouse (90%), Rat (90%), Dog (91%), Cat (93%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.

Specifications

• Antigen: MVP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MVP
• Gene Alias: 2310009M24Rik; LRP; Lung resistance-related protein; major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; VAULT1; vRNP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 78388, 9961
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q14764, Q9EQK5
• Gene Symbols: MVP
• Immunogen: Recombinant fragment corresponding to a region within amino acids 158 and 380 of MVP/LRP (Uniprot ID#Q14764).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov