Invitrogen™ Myc Tag Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA3981

Catalog No. 01-670-202

Description

PA3-981 detects c-Myc tagged proteins. PA3-981 has been successfully used in immunofluorescence, immunoprecipitation, and Western blot procedures. By Western blot it detects a ~41 kDa protein representing c-Myc. The PA3-981 immunogen is a synthetic peptide corresponding to residues M E Q K L I S E E D L G C of human c-Myc.

Myc is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Specifications

• Antigen: Myc Tag
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MYC
• Gene Alias: 46-0603; AU016757; avian myelocytomatosis viral oncogene homolog; bHLHe39; c Myc; class E basic helix-loop-helix protein 39; cmyc; c-Myc; c-myc epitope tag; c-myc proto-oncogene; MRTL; MYC; Myc protein; Myc proto-oncogene protein; Myc Tag; Myc2; MYCC; myc-related translation/localization regulatory factor; myelocytomatosis oncogene; Niard; Nird; Proto-oncogene c-Myc; R95025; R950-25; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog
• Host Species: Sheep
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Tag
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: Conc. Not Determined
• Formulation: PBS with 0.05% sodium azide; pH 7.4
• Gene Accession No.: P01106
• Gene Symbols: MYC
• Immunogen: Synthetic peptide corresponding to residues M E Q K L I S E E D L G C of human c-Myc.
• Regulatory Status: RUO
• Gene ID (Entrez): 4609
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Tag

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov