Myocilin Mouse anti-Human, Mouse, Porcine, Rat, Clone: 4B1F6, Proteintech

Catalog No.	Quantity
50-173-6443	150 μL

Catalog No. 50-173-6443 Supplier Proteintech Group Inc Supplier No. 603571IG150UL

Description

Mouse Monoclonal Antibody

Myocilin is an extracellular protein expressed in the eye, including the retina, trabecular meshwork and ciliary body. Myocilin can form homomultimers in vivo and can also associate with components of the ECM via interactions with the Hep II domain of FibroPVRL1. In addition, myocilin interacts with myosin regulatory light chain, a component of the myosin motor protein complex. This interaction implies a role for myocilin in the actomyosin system, linking myocilin to the functional status of the trabecular meshwork (TM), which is responsible for controlling the intraocular pressure (IOP). Alterations in functions of the TM may lead to IOP elevation and development of glaucoma, a major cause of blindness. Myocilin is encoded by MYOC (also designated TIGR), a gene that maps to the GLC1A locus on chromosome 1q24.3 and is susceptible to mutations. Mutations in the MYOC gene are specifically linked with primary open angle glaucoma (POAG), a blinding disease characterized by progressive loss of retinal ganglion cells.

Specifications

• Antigen: Myocilin
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 4B1F6
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MYOC
• Gene Accession No.: O70624, Q99972, Q9R1J4
• Gene Alias: GLC1A, GPOA, JOAG, JOAG1, MYOC, myocilin, TIGR
• Gene Symbols: Myoc
• Host Species: Mouse
• Immunogen: Myocilin Fusion Protein Ag5492
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17926, 397046, 4653, 81523
• Target Species: Human, Mouse, Pig, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a