Invitrogen™ MYZAP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521116

Catalog No. PIPA521116

Description

A suggested positive control is rat kidney tissue lysate. PA5-21116 can be used with blocking peptide PEP-1230.

MYOZAP, also known as GRINL1A, is a 54 kDa highly conserved cardiac protein. It is strongly expressed in the heart and lung and is a novel component of intercalated disc. MYOZAP interacts with myosin phosphatase-RhoA interacting protein (MRIP) and acts as an activator of Rho-dependent SRF signaling. Knockdown study in zebrafish results in cardiomyopathy with severe dysfunction. The MYOZAP gene is part of a complex transcript unit that includes the gene for glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A (GRINL1A). Transcription of this gene occurs at an upstream promoter, with two different groups of alternatively spliced variants: Gup for GRINL1A upstream transcripts and Gcom for GRINL1A combined transcripts.

Specifications

• Antigen: MYZAP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MYZAP
• Gene Alias: AA407270; AV006038; gcom; GCOM1; Gcom2; Gm640; GRINL1A; GRINL1A combined protein; GRINL1A complex locus 1; GRINL1A complex locus protein 1; GRINL1A complex locus upstream; GRINL1A upstream protein; Grinl1a7; Gup; myocardial intercalated disc protein; myocardial zonula adherens protein; myocardium-enriched ZO1-associated protein; myocardium-enriched zonula adherens protein; myocardium-enriched zonula occludens-1-associated protein; myozap; Myzap; MYZAP-POLR2M
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100820829, 102371, 363091
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P0CAP1, Q3UIJ9, Q5EB94
• Gene Symbols: MYZAP
• Immunogen: An 18 amino acid peptide near the carboxy terminus of human MYOZAP.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG