N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-Hydroxysuccinimide

Description

CAS: 74124-79-1 | C9H8N2O7 | 256.17 g/mol

N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
N,N′-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

Solubility
Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.

Notes
Moisture sensitive. Store in a cool place. Incompatible with strong acids and oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 74124-79-1
• Molecular Formula: C9H8N2O7
• Molecular Weight (g/mol): 256.17
• MDL Number: MFCD00009767
• InChI Key: PFYXSUNOLOJMDX-UHFFFAOYSA-N
• Synonym: n,n'-disuccinimidyl carbonate, bis 2,5-dioxopyrrolidin-1-yl carbonate, n,n'-disuccinimidylcarbonate, di succinimido carbonate, disuccinimidyl carbonate, di n-succinimidyl carbonate, n,n-disuccinimidyl carbonate, dsc, disuccinimido carbonate, pubchem12700
• PubChem CID: 676246
• IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) carbonate
• SMILES: C1CC(=O)N(C1=O)OC(=O)ON2C(=O)CCC2=O

• Melting Point: 190°C (decomposition)
• Quantity: 25 g
• Beilstein: 1499137
• Sensitivity: Hygroscopic
• Solubility Information: Soluble in dimethyl sulfoxide,hot pyridine,acetonitrile and most organic solvents. Insoluble in water.
• Formula Weight: 256.17
• Percent Purity: 85%
• Grade: Technical
• Assay: remainder N-Hydroxysuccinimide
• Chemical Name or Material: N,N'-Disuccinimidyl carbonate

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	277-730-3
TSCA	No
Recommended Storage	Keep cold; Store under Nitrogen

SDS

RUO – Research Use Only