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Invitrogen™ N-sulfated Heparan Sulfate Monoclonal Antibody (HepSS-1), Biotin
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Catalog No. PIMA546186
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100 μg
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PIMA546186 100 μg
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Catalog No. PIMA546186 Supplier Invitrogen™ Supplier No. MA546186
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Description

Mouse Monoclonal Antibody

This antibody recognizes N-sulfated heparan sulfate (extracellular antigen) present in many species.

Heparan sulfate (HS) is a glycosaminoglycan that is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane. Each HS molecule is a linear polysaccharide composed of repeating disaccharides of hexuronic acid and d-glucosamine that can exhibit immense structural diversity due to substitution to varying extents with sulfate groups and epimerization of glucuronic acid to iduronic acid, with areas of high sulfation and glucuronic acid epimerization being co-located in hot spots throughout the molecule. HS is structurally related to heparin, an extremely highly sulfated form of HS that is restricted to mast cells. The biosynthesis and modification of HS chains is thought to take place within the endoplasmic reticulum, Golgi apparatus, and trans Golgi network, which in the end produce unique HS chains that are covalently attached to a range of core proteins to form HS-proteoglycans [PMID: 24391644].
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Specifications

Antigen N-sulfated Heparan Sulfate
Applications Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone HepSS-1
Concentration 1 mg/mL
Conjugate Biotin
Formulation TBS with 15mM sodium azide; pH 8
Gene Alias Heparan sulfate
Host Species Mouse
Immunogen MethA murine fibrosarcoma.
Purification Method Size-exclusion chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgM
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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