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  6. N6AMT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech 

N6AMT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 501731291 Shop All Proteintech Group Inc Products
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50-173-1291 150 μL
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Catalog No. 50-173-1291 Supplier Proteintech Group Inc Supplier No. 169541AP150UL
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Description

Rabbit Polyclonal Antibody

Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintece of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.

Specifications

Antigen N6AMT2
Applications Western Blot
Classification Polyclonal
Concentration 0.13 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene EEF1AKMT1
Gene Accession No. Q8WVE0, Q9CY45
Gene Alias ESP13, N6AMT2
Gene Symbols Eef1akmt1
Host Species Rabbit
Immunogen N6AMT2 Fusion Protein Ag10589
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 221143, 290279, 68043
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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