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NAB2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
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Catalog No. 501732465 Shop All Proteintech Group Inc Products
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50-173-2465 150 μL
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Catalog No. 50-173-2465 Supplier Proteintech Group Inc Supplier No. 196011AP150UL
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Description

Rabbit Polyclonal Antibody

Transcriptional control is in part regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (for NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, are corepressors of EGF-1/NGFI-A. Both NAB1 and NAB2 contain an amino terminal NAB conserved domain 1 (NCB1), which is required for binding NGFI-A, and a carboxy terminal NCD2 domain, which is responsible for the repressor function of NAB proteins. NAB2 is principally localized in the nucleus and may play a role in the downregulation of NGFI-A activity as well as in controlling fundamental processes such as cell division, differentiation and apoptosis. NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3-14.1, a region that is rearranged in several solid tumors, lipomas and liposarcomas.

Specifications

Antigen NAB2
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NAB2
Gene Accession No. Q15742, Q61127
Gene Alias EGR 1 binding protein 2, MADER, NAB2, NGFI A binding protein 2, Protein MADER
Gene Symbols Nab2
Host Species Rabbit
Immunogen NAB2 Fusion Protein Ag6346
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17937, 314910, 4665
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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