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Invitrogen™ NALP7 Polyclonal Antibody
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Catalog No. PIPA588184
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100 μL
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PIPA588184 100 μL
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Catalog No. PIPA588184 Supplier Invitrogen™ Supplier No. PA588184
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: CRLTEASCKD LAAVLVVSKK LTHLCLAKNP IGDTGVKFLC EGLSYPDCKL QTLVLQQCSI TKLGCRYLSE ALQEACSLTN LDLSINQIAR GLWILCQALE NPNCNLKHLR LWSCSLMPFY CQHLGSALLS NQKLETLDLG QNHLWKSGII KLFGVLRQRT GSLKILRLKT YETNLEIKKL LEEVKEKNPK LTIDCNASGA T; Positive Samples: HeLa, U-87MG, 293T, Jurkat, Mouse brain.

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1-b secretion and is a feedback regulator of interleukin-1-b secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NALP7
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.24 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene NLRP7
Gene Accession No. Q8WX94
Gene Alias CLR19.4; HYDM; NACHT, leucine rich repeat and PYD containing 7; NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains-containing protein 7; NALP7; NLR family pyrin domain containing 7; NLR family, pyrin domain containing 7; NLRP7; NOD12; Nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7; PAN7; PYPAF3; PYRIN-containing APAF1-like protein 3
Gene Symbols NLRP7
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human NLRP7 (NP_6319152).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 199713
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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