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Nanog Mouse anti-Human, PE, Clone: N31-355, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 560873

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Catalog No. BDB560873


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Description

Description

The N31-355 monoclonal antibody reacts with human Nanog (named for Tir Na Nog, the land of the ever-young of Celtic mythology), which is a homeobox transcription factor required for the maintenance of the undifferentiated state of pluripotent stem cells. Nanog expression counteracts the differentiation-promoting signals induced by the extrinsic factors LIF (Leukemia Inhibitory Factor) and BMP (Bone Morphogenic Protein). When Nanog expression is down-regulated, cell differentiation can proceed. Proteins that regulate Nanog expression include transcription factors Oct4, SOX2, FoxD3, and Tcf3 and tumor suppressor p53. Nanog is one of the factors that can contribute to reprogramming of differentiated cells to an induced pluripotent stem cell state.

Specifications

Specifications

Nanog
N31-355
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Mouse
IgG1, κ
RUO
Primary
Human
Flow Cytometry
PE
Affinity Purified
Human Nanog Recombinant Protein
25 Tests
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
SDS
Documents
Product Certifications
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