Naringin

Description

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activity | CAS: 10236-47-2 | C27H32O14 | 580.54 g/mol

A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer's disease.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A citrus bioflavanoid that inhibits cytochrome P-450 monooxygenase activityNaringin is used to prepare naringin dihydrochalcone, which is about 300-1800 times sweeter than sugar. It is a citrus bioflavonoid reported to inhibit cytochrome P450 monooxygenase activity. It also acts as an inhibitor of cytochrome P450 enzymes. It is employed as an antioxidant, lipid lowering and anticancer agent. In addition to this, it is used in a study to assess aldosterone production by a human adrenocortical cell line and to improve cognitive deficits of Alzheimer′s disease.

Solubility
Soluble in water, alcohol, acetone and warm acetic acid.

Notes
Incompatible with strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 10236-47-2
• Molecular Formula: C27H32O14
• Molecular Weight (g/mol): 580.54
• MDL Number: MFCD00148888,MFCD00149445,MFCD01461988
• InChI Key: DFPMSGMNTNDNHN-ZPHOTFPESA-N
• Synonym: 4',5,7-Trihydroxyflavanone 7-rhamnoglucoside
• PubChem CID: 74787988
• IUPAC Name: 7-[(2S,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
• SMILES: C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2OC2=CC(O)=C3C(=O)C[C@H](OC3=C2)C2=CC=C(O)C=C2)[C@H](O)[C@H](O)[C@H]1O

• Color: White to Yellow
• Quantity: 25 g
• Beilstein: 102012
• Merck Index: 14,6425
• Solubility Information: Soluble in water,alcohol,acetone and warm acetic acid.
• Formula Weight: 580.53
• Physical Form: Powder
• Chemical Name or Material: Naringin

Safety and Handling

Hazard Category	Warning
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	GHS P Statement P261-P280-P305+P351+P338-P304+P340-P405-P501a Avoid breathing dust/fume/gas/mist/vapors/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
EINECSNumber	233-566-4
RTECSNumber	QN6340000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only