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Invitrogen™ NCAPD2 Polyclonal Antibody
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Catalog No. PIPA557919
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100 μL
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PIPA557919 100 μL
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Catalog No. PIPA557919 Supplier Invitrogen™ Supplier No. PA557919
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VGTIQCLEEI LCEFVQKDEL KPAVTQLLWE RATEKVACCP LERCSSVMLL GMMARGKPEI VGSNLDTLVS IGLDEKFPQD YRLAQQVCHA IANISDRRKP SLGKRH Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 92%.

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NCAPD2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene NCAPD2
Gene Accession No. Q15021
Gene Alias 2810406C15Rik; 2810465G24Rik; Capd2; CAP-D2; chromosome condensation related SMC associated protein 1; chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; CNAP1; Condensin complex subunit 1; hCAP-D2; KIAA0159; mCAP-D2; mKIAA0159; Ncapd2; Non-SMC condensin I complex subunit D2; non-SMC condensin I complex, subunit D2; RGD1562596; XCAP-D2 homolog
Gene Symbols NCAPD2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human NCAPD2. Recombinant protein control fragment (Product #RP-97626).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9918
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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