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NCAPH2 Monoclonal Antibody (5F2G4), Active Motif™
SDP

Catalog No. 501993615
Encompass
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50-199-3615 10 μg
50-199-3614 100 μg
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Catalog No. 50-199-3615 Supplier Active Motif Supplier No. 61682
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Description

Rat Monoclonal Antibody

Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.

Specifications

Antigen NCAPH2
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone 5F2G4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene NCAPH2
Gene Accession No. Q6IBW4
Gene Alias CAPH2; CAP-H2 subunit of the condensin II complex; Chromosome-associated protein H2; Condensin-2 complex subunit H2; CTA-384D8.36; D15Ertd785e; hCAP-H2; kleisin beta; Kleisin-beta; NCAPH2; Non-SMC condensin II complex subunit H2; non-SMC condensin II complex, subunit H2
Gene Symbols NCAPH2
Host Species Rat
Immunogen This antibody was raised against a recombinant protein to human NCAPH2.
Purification Method Protein G
Quantity 10 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29781
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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