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Invitrogen™ NCoR2 Polyclonal Antibody
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Catalog No. PA1843
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100 μg
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PA1843 100 μg
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Catalog No. PA1843 Supplier Invitrogen™ Supplier No. PA1843
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Description

Rabbit Polyclonal Antibody

PA1-843 detects silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) from human and mouse cells. PA1-843 has been successfully used in Western blot, ICC/IF and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects an ~250 kDa protein representing SMRT from HeLa cell nuclear extracts. The PA1-843 antigen is His-tagged fusion protein corresponding to amino acid residues 95-565 from human SMRT.

Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) and nuclear receptor corepressor (N-CoR) are related transcriptional corepressors which contain two distinct domains capable of interacting with unliganded nuclear receptors to repress their basal transcriptional activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NCoR2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene NCOR2
Gene Accession No. Q9WU42, Q9Y618
Gene Alias CTG repeat protein 26; CTG26; N-CoR; NCOR2; N-CoR2; nuclear receptor corepressor; nuclear receptor corepressor 2; nuclear receptor co-repressor 2; silencing mediator for retinoid and thyroid hormone receptors; silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; SMAP270; SMRT; SMRTe; SMRTE-tau; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TNRC14; TRAC; TRAC1; TRAC-1
Gene Symbols NCOR2
Host Species Rabbit
Immunogen His-tagged fusion protein corresponding to amino acid residues 95-565 from human SMRT.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20602, 9612
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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