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Necrostatin-1

Catalog No. AAJ65341FPL
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AAJ65341FPL 20 mg
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Catalog No. AAJ65341FPL Supplier Thermo Scientific Chemicals Supplier No. J65341FPL
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Description

CAS: 4311-88-0 | C13H13N3OS | 259.327 g/mol

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 4311-88-0
Molecular Formula C13H13N3OS
Molecular Weight (g/mol) 259.327
MDL Number MFCD00056916
InChI Key TXUWMXQFNYDOEZ-UHFFFAOYSA-N
Synonym necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
PubChem CID 2828334
IUPAC Name 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
SMILES CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

Specifications

Color Yellow
Quantity 20 mg
Sensitivity Light sensitive
Solubility Information Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml).
Formula Weight 259.33
Physical Form Powder
Chemical Name or Material Necrostatin-1

Safety and Handling

TSCA No
storageNote1 2° to 8°C
Recommended Storage Keep cold
SDS

RUO – Research Use Only

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