Necrostatin-1

Description

CAS: 4311-88-0 | C13H13N3OS | 259.327 g/mol

Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any perturbation of the Fas/TNFR triggered canonical apoptosis cascade.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Necrostatin-1 functions as an allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP (RIP1) in the necroptosis pathway. While affecting this distinct cell death pathway, Necrostatin-1 does not present any pe

Specifications

Chemical Identifiers

• CAS: 4311-88-0
• Molecular Formula: C13H13N3OS
• Molecular Weight (g/mol): 259.327
• MDL Number: MFCD00056916
• InChI Key: TXUWMXQFNYDOEZ-UHFFFAOYSA-N
• Synonym: necrostatin-1, mth-dl-tryptophan, nec-1, necrostatin 1, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo-4-imidazolidinone, mth-trp, methyl-thiohydantoin-tryptophan, necroptotic inhibitor, nec-1, 5-1h-indol-3-ylmethyl-3-methyl-2-sulfanylideneimidazolidin-4-one, 4-imidazolidinone, 5-1h-indol-3-ylmethyl-3-methyl-2-thioxo
• PubChem CID: 2828334
• IUPAC Name: 5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
• SMILES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32

• Color: Yellow
• Quantity: 20 mg
• Sensitivity: Light sensitive
• Solubility Information: Soluble in DMSO (10-25mg/ml),100% ethanol (6mg/ml),and methanol (5mg/ml).
• Formula Weight: 259.33
• Physical Form: Powder
• Chemical Name or Material: Necrostatin-1

Safety and Handling

TSCA	No
storageNote1	2° to 8°C
Recommended Storage	Keep cold

SDS

RUO – Research Use Only