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Invitrogen™ Nectin 4 Recombinant Rabbit Monoclonal Antibody (PSH09-73)
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Catalog No. MA570098
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MA570098 100 μL
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Catalog No. MA570098 Supplier Invitrogen™ Supplier No. MA570098
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Description

Rabbit Recombinant Monoclonal Antibody

Positive control: MCF7 cell lysate, T-47D cell lysate, human placenta tissue, human skin tissue. Subcellular location: Cell membrane, Cell junction, adherens junction, Secreted.

Nectin 4 (PVRL4) is a gene located on chromosome 1q23.3 that encodes a member of the nectin family of cellular adhesion molecules. These proteins are primarily involved in forming adherens junctions between epithelial cells, contributing to tissue integrity and maintenance in various tissues, including the skin, lungs, and mammary glands. Nectin 4 is highly expressed during embryonic development and is crucial for processes like tissue morphogenesis and repair. It acts as a ligand for the poliovirus receptor-related family and participates in cell signaling pathways that influence cell proliferation and survival. In the context of cancer, Nectin 4 is often upregulated, particularly in breast, ovarian, and lung cancers, where its expression is associated with tumor progression, metastasis, and poor prognosis. This makes Nectin 4 a potential target for therapeutic interventions and a candidate biomarker for cancer diagnosis and monitoring.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nectin 4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone PSH09-73
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide, pH 7.4
Gene NECTIN4
Gene Accession No. Q96NY8
Gene Alias 1200017F15Rik, EDSS1, ig superfamily receptor LNIR, LNIR, nectin 4, nectin cell adhesion molecule 4, NECTIN4, Nectin-4, poliovirus receptor-related 4, poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, PRR4, Pvrl4, RGD1559826
Gene Symbols NECTIN4
Host Species Rabbit
Immunogen Recombinant protein within human Nectin-4 aa 1-400.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 81607
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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