NEDD4 Monoclonal Antibody (OTI6B2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA812644

Catalog No. 50-168-4632

Description

The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.

Specifications

• Antigen: NEDD4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P46934
• Gene Symbols: NEDD4
• Immunogen: Human recombit protein fragment corresponding to amino acids 160-460 of human NEDD4 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI6B2
• Conjugate: Unconjugated
• Gene: NEDD4
• Gene Alias: NEDD4-1, RPF1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4734
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid