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NEEP21 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988362
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50-198-8362 100 μL
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Catalog No. 50-198-8362 Supplier Bioss Supplier No. BS8204R
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Description

Rabbit Polyclonal Antibody

NEEP21 (neuron-enriched endosomal 21kDa protein), also known as brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (Neurotensin receptor 2).

Specifications

Antigen NEEP21
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene NSG1
Gene Accession No. P42857
Gene Alias brain neuron cytoplasmic protein 1; Brain neuron cytoplasmic protein 1/2; brain specific mRNA b; Bsmrb; carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; D4S234; D4S234E; M234; NEEP21; neuron specific gene family member 1; Neuronal vesicle trafficking-associated protein 1; Neuron-enriched endosomal protein of 21 kDa; Neuron-specific protein family member 1; NSG1; p21; PEP1
Gene Symbols NSG1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human NEEP21.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27065
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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