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Lkt Laboratories CAS 1405-10-3, ≥98%, Inhibitor of protein translation inhibitor, TRPV1 receptors, and P2X receptors.
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Supplier:  Lkt Laboratories N1755

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Neomycin is a polycationic aminoglycoside antibiotic that exhibits antibacterial and neuromodulatory activities; it was originally found in species of Streptomyces.  Neomycin binds to 23S rRNA, constraining tRNA in the P-site, inhibiting translocation and ribosomal recycling; together, this results in inhibition of protein synthesis. Neomycin B binds and inhibits bacterial RNase P and bacterial T box antiterminator RNA. Neomycin B inhibits mammalian RNA splicing as well. Neomycin also noncompetitively inhibits cation channels, including P2X receptors and transient receptor potential vanilloid receptor 1 (TRPV1) channels. Additionally, this compound inhibits Ca2+ influx, preventing presynaptic release of acetylcholine and norepinephrine in feline superior cervical ganglia.

Catalog No. NC2539825


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