Neomycin sulfate hydrate

Description

CAS: 1405-10-3 | C23H48N6O17S | 712.72 g/mol

Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits Phospholipase C via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits Phospholipase C via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation.

Solubility
Soluble in water

Notes
Research Use only: Not intended for animal or human diagnostic or therapeutic use.

Specifications

Chemical Identifiers

• CAS: 1405-10-3
• Molecular Formula: C23H48N6O17S
• Molecular Weight (g/mol): 712.72
• MDL Number: MFCD29905465
• InChI Key: OIXVKQDWLFHVGR-DJUBFIBWNA-N
• PubChem CID: 124080932
• SMILES: OS(O)(=O)=O.NCC1OC(O[C@@H]2[C@@H](CO)O[C@@H](OC3C(O)C(N)CC(N)C3OC3OC(CN)C(O)C(O)C3N)[C@@H]2O)C(N)C(O)C1O

• Type: Neomycin Sulfate
• Physical Form: Powder
• Color: White
• Quantity: 25 g
• Merck Index: 14,6454
• Solubility Information: Soluble in water
• IUPAC Name: 5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-[(3,5-diamino-2-{[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl)oxy]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; sulfuric acid
• Formula Weight: 908.87 (Anhydrous)
• Chemical Name or Material: Neomycin sulfate hydrate

Safety and Handling

Hazard Category	H317-H334-H361d-H373
Hazard Statement	GHS H Statement H334-H317 May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.
Precautionary Statement	P201-P202-P260-P272-P280g-P281-P285-P302+P352-P304+P341-P308+P313-P333+P313-P342+P311-P363-P501c
EINECSNumber	215-773-1
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only