Neomycin Sulfate, MP Biomedicals™

Description

Acts against both gram-positive and gram-negative bacteria. Neomycin Sulfate, MP Biomedicals is produced by Streptomyces containing a minimum of 85% neomycin B.

This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.

Applications:

• As a selection agent for prokaryotic cells transformed using the neo selectable marker gene
• To study ototoxic side effects of antibiotics and platelet-derived growth factor responses in certain fibroblasts
• In the extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins
• It is recommended for use in cell culture applications at 50mg/L

Specifications

Chemical Identifiers

• CAS: 1405-10-3
• Molecular Formula: C23H48N6O17S
• Molecular Weight (g/mol): 712.72
• MDL Number: MFCD29905465
• InChI Key: OIXVKQDWLFHVGR-DJUBFIBWNA-N
• PubChem CID: 124080932
• SMILES: OS(O)(=O)=O.NCC1OC(O[C@@H]2[C@@H](CO)O[C@@H](OC3C(O)C(N)CC(N)C3OC3OC(CN)C(O)C(O)C3N)[C@@H]2O)C(N)C(O)C1O

• Physical Form: Powder
• pH: 5 to 7.5
• Loss on Drying: <8.0%
• Quantity: 1 g
• Solubility Information: H2O soluble (50mg/mL)
• IUPAC Name: 5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-[(3,5-diamino-2-{[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl)oxy]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; sulfuric acid
• Formula Weight: 908.9g/mol
• Grade: USP

Safety and Handling

Recommended Storage

Room Temperature, desiccate, C3696

WARNING: Reproductive Harm - www.P65Warnings.ca.gov