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Invitrogen™ Neurocan Polyclonal Antibody
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Catalog No. PIPA536994
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100 μL
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PIPA536994 100 μL
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Catalog No. PIPA536994 Supplier Invitrogen™ Supplier No. PA536994
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 220 kDa (full length) and 140 kDa (proteolytic variant). Purity is >95% by SDS-PAGE.

Neurocan is a gene encoding a large chondroitin sulfate proteoglycan, predominantly expressed in the central nervous system. Located on chromosome 19 in humans, neurocan is part of the lectican family of proteoglycans, integral to the extracellular matrix where they modulate neuronal cell adhesion and migration. This proteoglycan is essential in the formation of the neural network during development and in maintaining the plasticity of the extracellular matrix in adult brains. Neurocan undergoes proteolytic processing, resulting in various fragments that influence neuronal growth and synapse stabilization. Altered neurocan expression has been linked to several neurological conditions such as schizophrenia, bipolar disorder, and Alzheimer's disease, likely due to its role in synaptic function and integrity of the neural matrix. Understanding neurocan's exact roles in neurological health and disease could illuminate pathways for potential therapeutic interventions targeting matrix remodeling and neuronal connectivity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Neurocan
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide
Gene Ncan
Gene Accession No. O14594, P55066, P55067
Gene Alias 245 kDa early postnatal core glycoprotein; C230035B04; Chondroitin sulfate proteoglycan 3; chondroitin sulfate proteoglycan 3 (neurocan); chondroitin sulfate proteoglycan 3, related sequence; Cspg3; Cspg3-rs; NCAN; NEUR; neurocan; neurocan core protein; neurocan proteoglycan; TGFbeta-induced transcript, brain; Tgfbit
Gene Symbols Ncan
Host Species Rabbit
Immunogen Synthetic peptide corresponding to amino acids 440-485 of human Neurocan.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13004, 1463, 58982
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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