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CPC Scientific H-Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-OH (trifluoroacetate salt) 5MG
Supplier: CPC Scientific NEUP013B
This peptide is an endogenous ligand of the G-protein-coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricular administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release.ONE-LETTER SEQUENCE: WYKHVASPRYHTVGRAAGLLMGLMOLECULAR FORMULA: C119H183N35O28S1MOLECULAR WEIGHT:2584.05STORAGE CONDITIONS: -20 5C, CAS REGISTRY NUMBER: [383415-79-0], RESEARCH AREA: NeuropeptidesREFERENCES: .Shimomura et al., J. Biol. Chem., 277, 35826 (2002); S.Brezillon et al., J. Biol. Chem., 278, 776 (2003); H.Tanaka et al., Proc. Natl. Acad. Sci. USA, 100, 6251 (2003); M.S.Mondal et al., Endocrinology, 144, 4729 (2003)
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