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Abcam NF-kappaB Activation Inhibitor VI, Benzoxathiole Compound, Solid, 5 mg

Catalog No. 502583246
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50-258-3246 5 mg
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Catalog No. 50-258-3246 Supplier Abcam Supplier No. AB1459545MG
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Description

Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor to block NF-κB activation.

  • Molecular weight: 273.4 Da
  • Purity: >95%
  • Form: Solid
  • Mechanism: Cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser177 and/or Ser181 residues in the kinase activation loop domain.
  • Activity: Inhibits LPS-induced NF-κB activation (IC50 = 1.0 μM) and nitrite production (IC50 = 0.7 μM) in RAW 264.7 cells in vitro and effectively prevents LPS-induced septic death in mice in vivo.

The product is subject to the following: Abcam Restricted Use Statement

Specifications

Target Molecule IKK-2
Substrate Properties Chemical Substrate
Content And Storage Store at 4°C.
Form Solid
Shipping Condition Ambient
Quantity 5 mg
For Use With (Application) NF-κB pathway inhibition, IKK-2 inhibition
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