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Invitrogen™ NF2 Recombinant Rabbit Monoclonal Antibody (1H27L4)

Catalog No. PI702466 Shop All Thermo Scientific Products
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PI702466 100 μg
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Catalog No. PI702466 Supplier Invitrogen™ Supplier No. 702466
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Pig, Horse, Mouse Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

NF2 encodes a protein, Merlin, that is similar to some members of the ERM family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. Merlin has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NF2
Applications Flow Cytometry, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 1H27L4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene Nf2
Gene Accession No. P35240, P46662, Q63648
Gene Alias ACN; BANF; Merlin; MGC123124; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromatosis 2; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); neurofibromin 2b (merlin); neurofibromin-2; Nf2; Nf-2; NF2a; nf2b; OTTHUMP00000199607; SCH; Schwannomerlin; schwannomin
Gene Symbols Nf2
Host Species Rabbit
Immunogen Protein corresponding to human NF2 [aa331-aa530].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18016, 25744, 4771
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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