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NF90/NF110 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A303121AT

Encompass_Preferred

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Catalog No. 50-156-4314


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

NF90 (nuclear factor of activated T-cells 90 kDa), also known as NFAR, DRBF, DRBP76 (double-stranded RNA-binding protein 76), MPP4, MPHOSPH4 (M-phase phosphoprotein 4), ILF3 (interleukin enhancer binding factor 3) or TCP80 (translational control protein 80), is a ubiquitously expressed nuclear protein that exists in a heterodimer with NF45. NF90 contains two DRBM (double-stranded RNA(dsRNA-)-binding) domains and one DZF domain and, in association with NF45 primarily participates in the regulation of IL-2 expression by binding to the antigen receptor response element (ARRE) target sequence of the IL-2 enhancer. In neuronal cells, the NF45/NF90 heterodimer can repress human rhinovirus type 2 replication by binding to a 5′ untranslated region of the viral RNA that encodes the internal ribosome entry site (IRES). NF45 and NF90 belong to the double-stranded RNA-binding protein family and both are substrates for the dsRNA-activated protein kinase, PKR. Due to alternative splicing events, six isoforms exist for NF90, namely NFAR-2 (or ILF3-E), NFAR-1 (or DRBP76), isoform 3, DRBP76 alpha (or ILF3-A), DRBP76 delta (also known as DRBP76 gamma or ILF3-C) and isoform 6.
Specifications

Specifications

NF90/NF110
Polyclonal
TBS with 0.1% BSA and 0.09% sodium azide
Q12906, Q9Z1X4
ILF3
Between 325 and 375
20 μL
Primary
Human, Mouse
Antibody
IgG
Immunohistochemistry, Western Blot
Unconjugated
ILF3
Interleukin enhancer-binding factor 3, Double-stranded RNA-binding protein 76, DRBP76, M-phase phosphoprotein 4, MPP4, Nuclear factor associated with dsRNA, NFAR, Nuclear factor of activated T-cells 90 kDa, NF-AT-90, Translational control protein 80, TCP80, DRBF, MPHOSPH4, NF90
Rabbit
Antigen affinity chromatography
RUO
16201, 3609
4° C
Liquid
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