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Tocris Bioscience™ NFAT inhibitor, Cell Permeable
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Catalog No. 57101
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57-101 1 mg
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Catalog No. 57-101 Supplier Tocris Bioscience™ Supplier No. 5710/1
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Description

Cell permeable NFAT inhibitor

NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.

Specifications

CAS 592517-80-1
Content And Storage Store at -20°C
Description Protein Ser/Thr Phosphatase Inhibitors
Molecular Weight (g/mol) Observed M.W.: 3573.15
Quantity 1 mg
Structural Form C147H259N67O36S
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