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NFkB p65 Rabbit anti-Human, Unconjugated, Polyclonal, Active Motif™ Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

$135.30 - $546.00

Specifications

Monoclonal or Polyclonal Polyclonal
Primary or Secondary Primary
Antigen NFkB p65
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-199-4009 Non-distribution product as customer accommodation.
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Active MotifSupplier Diversity Partner
39370
10 μL
Each for $135.30
Add to cart
 
50-199-4008 Non-distribution product as customer accommodation.
View Documents
Active MotifSupplier Diversity Partner
39369
100 μL
Each for $546.00
Add to cart
 
Description

Description

Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is present on chromosome 11 in humans. NF-kB P65 is also known as RelA (v-rel avian reticuloendotheliosis viral oncogene homolog A) and belongs to the Rel family of proteins. It is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells) that heterodimerizes with the other subunits p50 or p52. However, binding of TNF alpha to its cognate receptor phosphorylates IKK which in turn phosphorylates I kB allowing proteasomal degradation of I kB. Phosphorylation of p65 at Ser 536 located in the carboxy-terminal transactivation domains (TAD) leads to nuclear localization of the transcriptionally active complex and NF-kB mediated transactivation of several downstream genes. It specifically plays a key role in transcription of immunoglobulin k (kappa) gene in mature B-lymphoid cells.
Specifications

Specifications

Polyclonal
Primary
NFkB p65
Unconjugated
SDS
Product Certifications
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