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Invitrogen™ NGEF Polyclonal Antibody
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Catalog No. PIPA5143696
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100 μL
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PIPA5143696 100 μL
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Catalog No. PIPA5143696 Supplier Invitrogen™ Supplier No. PA5143696
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Description

Rabbit Polyclonal Antibody

The antibody detects an 80 kDa* band corresponding to ephexin-1 in Western blots of human A431, Jurkat, and HUVEC cells, as well as rat PC12 cells and mouse brain tissue.

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NGEF
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene NGEF
Gene Accession No. Q5BKC9, Q8CHT1, Q8N5V2
Gene Alias ARHGEF27; Besh3; brain-enriched SH3-domain protein Besh3; ephexin; ephexin-1; eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; Ngef; Tims2; transforming immortalised mammary epithelial sequence 2
Gene Symbols NGEF
Host Species Rabbit
Immunogen Ephexin-1 synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminal region of mouse ephexin-1. This sequence has significant homology to the same region in human and rat ephexin-1, and has low homology to other known proteins.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 246217, 25791, 53972
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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