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NGEF Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501728616 Shop All Proteintech Group Inc Products
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50-172-8616 150 μL
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Catalog No. 50-172-8616 Supplier Proteintech Group Inc Supplier No. 132711AP150UL
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Description

Rabbit Polyclonal Antibody

Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.

Specifications

Antigen NGEF
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.33 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene NGEF
Gene Accession No. Q8CHT1, Q8N5V2
Gene Alias EPHEXIN, Ephexin 1, NGEF
Gene Symbols NGEF
Host Species Rabbit
Immunogen NGEF Fusion Protein Ag3967
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25791, 53972
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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