Invitrogen™ NGF Polyclonal Antibody

Catalog No.	Quantity
01-674-399	500 μg

Catalog No. 01-674-399 Supplier Invitrogen™ Supplier No. PA19516

Description

Chicken Polyclonal Antibody

PA1-9516 detects Nerve growth factor in human, mouse and rat samples. PA1-9516 has been successfully used in Western blot, Immunohistochemistry and ELISA procedures. The PA1-9516 immunogen is a synthetic peptides corresponding to residues 74-85 & 113-124 of mouse NGF protein.

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.

Specifications

• Antigen: NGF
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: NGF
• Gene Accession No.: P01138, P01139, P25427
• Gene Alias: B nerve growth factor; beta ngf; beta-nerve growth factor; BetaNGF; beta-NGF; bNGF; b-NGF; HSAN5; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta polypeptide; nerve growth factor, beta subunit; NGF; NGF b; NGF β; Ngfb; NGFbeta; NGFβ; β nerve growth factor; β NGF; βNGF
• Gene Symbols: NGF
• Host Species: Chicken
• Immunogen: Synthetic peptides corresponding to residues 74-85 & 113-124 of mouse NGF protein.
• Purification Method: IgY fraction
• Quantity: 500 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18049, 310738, 4803
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgY

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov