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Invitrogen™ Nicastrin Recombinant Rabbit Monoclonal Antibody (002), FITC
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Catalog No. PIMA540999
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Quantity:
100 Tests
Catalog No. Quantity
PIMA540999 100 Tests
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Catalog No. PIMA540999

Supplier: Invitrogen™ MA540999

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Description

Rabbit Recombinant Monoclonal Antibody

May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nicastrin
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone 002
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 0.5% BSA and 0.03% ProClin 300
Gene NCSTN
Gene Accession No. Q92542
Gene Alias 9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
Gene Symbols NCSTN
Host Species Rabbit
Immunogen Recombinant Human Nicastrin/NCSTN protein.
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23385
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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