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Niclosamide, MP Biomedicals™

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Quantity:
50g
100g
250g
50-65-7
C13H8Cl2N2O4
327.12
MFCD00057597
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
2´,5-Dichloro-4-nitrosalicylanilide
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O
50-65-7
C13H8Cl2N2O4
327.12
MFCD00057597
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
2´,5-Dichloro-4-nitrosalicylanilide
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O

Niclosamide ≥98%, Greenish-Yellow Powder

  • It is used to study the Wnt/Frizzled-1 signaling pathway.
  • It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and to induce apoptosis.
  • It is effective against cestodes that infect humans.
  • Niclosamide uncouples oxidative phosphorylation in the tapeworm.
  • It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
  • It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells.
  • Niclosamide inhibits the transcription and DNA binding of NF-κB.
  • It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.
Color Green-yellow
Melting Point 225°C to 233°C
Loss on Drying ≤0.5%
UN Number UN3077
Beilstein 2820605
Quantity 100g
Solubility Information Soluble in methanol:acetone [1:1] (50mg/mL).
Sulfated Ash ≤0.1%
Vapor Pressure Very low at room temp

RTECSNumber : VN8400000

storageNote1 : Store at Room Temperature (15-30°C).