Niclosamide, MP Biomedicals™

Description

Niclosamide ≥98%, Greenish-Yellow Powder

• It is used to study the Wnt/Frizzled-1 signaling pathway.
• It is used to inhibit the transcription and DNA binding of NF-κB in AML cells and to induce apoptosis.
• It is effective against cestodes that infect humans.
• Niclosamide uncouples oxidative phosphorylation in the tapeworm.
• It inhibits mitochondrial oxidative phosphorylation of parasitic helminths.
• It inhibits the NF-κB pathway in acute myelogenous leukemia (AML) cells.
• Niclosamide inhibits the transcription and DNA binding of NF-κB.
• It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κB– regulated genes in AML cells. It increases ROS levels to induce apoptosis in AML cells.

Specifications

Chemical Identifiers

• CAS: 50-65-7
• Molecular Formula: C13H8Cl2N2O4
• Molecular Weight (g/mol): 327.12
• MDL Number: MFCD00057597
• InChI Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
• Synonym: 2´,5-Dichloro-4-nitrosalicylanilide
• IUPAC Name: 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
• SMILES: OC1=CC=C(Cl)C=C1C(=O)NC1=CC=C(C=C1Cl)[N+]([O-])=O

• Melting Point: 225°C to 233°C
• Color: Green-yellow
• Loss on Drying: ≤0.5%
• Quantity: 250 g
• UN Number: UN3077
• Beilstein: 2820605
• Solubility Information: Soluble in methanol:acetone [1:1] (50mg/mL).
• Vapor Pressure: Very low at room temp

Safety and Handling

RTECSNumber	VN8400000
storageNote1	Store at Room Temperature (15-30°C).

WARNING: Reproductive Harm - www.P65Warnings.ca.gov