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Apexbio Technology LLC PIK-294 900185-02-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B21885.1
PIK-294 (CAS 900185-02-6) is a potent and highly selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) isoform p110 with an IC50 of 10 nM It exhibits substantially reduced activity against PI3K PI3K and PI3K demonstrating a 1 000-fold 49-fold and 16-fold lower potency respectively Biochemical studies indicate that PIK-294 interacts with a high-affinity pocket in the ATP-binding site contributing to its inhibitory properties in vitro Used as a chemical probe PIK-294 aids in delineating isoform-specific PI3K functions such as the distinct roles of PI3K isoforms in insulin signaling and cellular differentiation pathways No clinical studies have been reported
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