Niflumic acid, 99+%

Description

CAS: 4394-00-7 | C13H9F3N2O2 | 282.22 g/mol

It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
It is used as a selective Cox-2 inhibitor and GPR35 activator. Also activates human TRPA1 inducibly expressed in HEK293 cells; displays agonist activity at GPR35.

Solubility
Soluble in ethanol (∼50 mg/ml), acetone (50 mg/ml, Clear to Slightly Hazy, Yellow), methanol (∼50 mg/ml), DMSO (56 mg/ml at 25°C), and acetonitrile (∼50 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Hygroscopic. Keep away fom strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 4394-00-7
• Molecular Formula: C13H9F3N2O2
• Molecular Weight (g/mol): 282.22
• MDL Number: MFCD00010569
• InChI Key: JZFPYUNJRRFVQU-UHFFFAOYSA-N
• Synonym: niflumic acid, nifluril, landruma, forenol, actol, acido niflumico, nifluminic acid, acide niflumique, acidum niflumicum, acide niflumique inn-french
• PubChem CID: 4488
• ChEBI: CHEBI:34888
• IUPAC Name: 2-{[3-(trifluoromethyl)phenyl]amino}pyridine-3-carboxylic acid
• SMILES: OC(=O)C1=CC=CN=C1NC1=CC=CC(=C1)C(F)(F)F

• Melting Point: 203°C to 204°C
• Color: Yellow
• Quantity: 50 g
• UN Number: UN2811
• Sensitivity: Light sensitive
• Merck Index: 14,6531
• Solubility Information: Soluble in ethanol (∽50mg/ml),acetone (50mg/ml,Clear to Slightly Hazy,Yellow),methanol (∽50mg/ml),DMSO (56mg/ml at 25°C),and acetonitrile (∽50mg/ml).
• Formula Weight: 282.22
• Percent Purity: ≥99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Niflumic acid

Safety and Handling

Hazard Category	H302+H312+H332-H315-H319-H335
Hazard Statement	GHS H Statement H301-H312-H332-H315-H319-H335 Toxic if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	224-516-2
RTECSNumber	QT2999100
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only