Invitrogen™ NIK Polyclonal Antibody

Catalog No.	Quantity
PIPA5110932	100 μL

Catalog No. PIPA5110932 Supplier Invitrogen™ Supplier No. PA5110932

Description

Rabbit Polyclonal Antibody

Immunogen sequence: SVYKLEAVEK SPVFCGKWEI LNDVITKGTA KEGSEAGPAA ISIIAQAECE NSQEFSPTFS ERIFIAGSKQ YSQSESLDQI PNNVAHA Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Specifications

• Antigen: NIK
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: MAP3K14
• Gene Accession No.: Q99558
• Gene Alias: aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
• Gene Symbols: MAP3K14
• Host Species: Rabbit
• Immunogen: Recombinant Protein corresonding to Human NIK. Recombinant protein control fragment (Product #RP-108163).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9020
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG