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Invitrogen™ NIK Polyclonal Antibody
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Catalog No. p-7184236
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100 μL
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Catalog No. Quantity
PIPA5110932 100 μL
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Catalog No. PIPA5110932 Supplier Invitrogen™ Supplier No. PA5110932
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SVYKLEAVEK SPVFCGKWEI LNDVITKGTA KEGSEAGPAA ISIIAQAECE NSQEFSPTFS ERIFIAGSKQ YSQSESLDQI PNNVAHA Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NIK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MAP3K14
Gene Accession No. Q99558
Gene Alias aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
Gene Symbols MAP3K14
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human NIK. Recombinant protein control fragment (Product #RP-108163).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9020
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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