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Invitrogen™ Nkx2.1 Monoclonal Antibody (8G7G3/1)
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Catalog No. 180221
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18-022-1 1 mL
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Catalog No. 18-022-1 Supplier Invitrogen™ Supplier No. 180221
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Description

Mouse Monoclonal Antibody

TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes. TTF-1 is found in primary lung adenocarcinomas and small cell carcinomas. TTF-1 is usually absent in breast and colon carcinomas. TTF-1 monoclonal antibody should be useful in differentiating tumors of lung and non-lung origin. Lung cancer and thyroid gland tissues have been identified positive for TTF-1 monoclonal antibody concentrate.

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Nkx2.1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 8G7G3/1
Conjugate Unconjugated
Description TTF-1 Mouse Monoclonal Antibody, 1mL, Liquid, Concentrate Antibody Dilution, 8G7G3/1 Clone, IgG1 Isotype, Mouse Host, Human Reactivity, Unconjugated, Used For Immunohistochemistry (FFPE) and Anatomical Pathology
Dilution Concentrate Antibody
Formulation PBS with 1% BSA and 0.1% sodium azide
Gene NKX2-1
Gene Accession No. P43699
Gene Alias AV026640; BCH; BHC; homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK2 homeobox 1; NK-2 homolog A; NKX2.1; Nkx-2.1; NKX2-1; NKX2A; NMTC1; RNA polymerase I transcription termination factor; T/EBP; TEBP; Thyroid nuclear factor 1; thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; thyroid transcription factor 1-like; thyroid-specific enhancer-binding protein; tinman; TITF1; TTF1; TTF-1
Gene Symbols NKX2-1
Host Species Mouse
Immunogen Recombinant full length TTF-1 (Thyroid Transcription Factor 1) protein.
Positive Control TTF-1 monoclonal antibody concentrate
Purification Method Purified
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 7080
Packaging 1 Each
Includes 0.1% Sodium azide
Target Species Human
Content And Storage 2-8°C
Product Type Antibody
Form Liquid
Isotype IgG1
Host abrv Ms
Reactivity Human
Shipping Condition Wet Ice
Reactivity abrv Hu
Target Gene TTF-1 (Thyroid Transcription Factor 1)
Validated Application abrv IHC (FFPE)
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