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Invitrogen™ NMDAR2B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ A6474

Encompass_Preferred

Catalog No. A6474


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Description

Description

This antibody is specific for the ~180 kDa 2B subunit from rat, mouse and human. Storage and reconstitution: when stored at -20ºC or below, the lyophilized antibody should retain full activity for over one year. Reconstitute using 50 μL PBS, pH 7.4, to yield a 0.2 mg/mL solution. If storing at 0-4ºC, add sodium azide to a final concentration of 2mM. For longer storage, divide the solution into aliquots and freeze at -20ºC, avoiding freeze/thaw cycles.

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer's Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NMDAR2B
Polyclonal
PBS with no preservative
Q00960, Q01097, Q13224
GRIN2B
Fusion protein containing amino acid residues 984-1104 of the C-terminal region of rat brain subunit 2B.
10 μg
Primary
Human, Mouse, Rat
Antibody
IgG
ELISA, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Unconjugated
GRIN2B
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3
Rabbit
IgG fraction
RUO
14812, 24410, 2904
-20°C
Lyophilized
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