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AdipoGen NMNAT2 human pAb
Supplier: AdipoGen AG25A0113C100
Polyclonal Antibody. Recognizes human NMNAT2. Detects a band of ~35kDa by Western blot. Not tested in other species. Source Guinea pig. Applications ELISA, IHC, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. NMNAT2 catalyzes the formation of NAD from nicotinamide mononucleotide NMN and ATP. Can also use the deamidated form nicotinic acid mononucleotide NaMN as a substrate but with lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD. Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. Has been shown to correlate with Alzheimer’s disease in APPswe/PS1dE9 transgenic mice and delayed wallerian degeneration in cultured superior cervical ganglia SCGs from morphological changes, microtubule destruction and neurofilament degradation.
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