Invitrogen™ NO66 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564895

Catalog No. PIPA564895

Description

Immunogen sequence: RVVETSALLCT AQHLAAVQSS GAPATASGPQ VDNTGGEPAW DSPLRRVLAE LNRIPSSRRR AARLFEWLIA PMPPDHFYRR LWEREAVLVR RQDHTYYQGL FSTADLDSML RNEEVQFGQH LDAARYINGR R Highest antigen sequence identity to the following orthologs - mouse 61%, rat 66%.

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt].

Specifications

• Antigen: NO66
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RIOX1
• Gene Alias: 2410016O06Rik; 60S ribosomal protein L8 histidine hydroxylase; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; C14orf169; chromosome 14 open reading frame 169; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; Mapjd; MNCb-7109; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; NO66; nucleolar protein 66; RGD1307704; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; RIKEN cDNA 2410016O06 gene; Riox1; ROX; similar to RIKEN cDNA 2410016O06; up-regulated in lung cancer 2; URLC2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79697
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H6W3
• Gene Symbols: RIOX1
• Immunogen: Recombinant Human NO66. Recombinant protein control fragment (Product #RP-105694).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov