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Invitrogen™ NO66 Polyclonal Antibody
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Catalog No. PIPA564895
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100 μL
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PIPA564895 100 μL
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Catalog No. PIPA564895 Supplier Invitrogen™ Supplier No. PA564895
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RVVETSALLCT AQHLAAVQSS GAPATASGPQ VDNTGGEPAW DSPLRRVLAE LNRIPSSRRR AARLFEWLIA PMPPDHFYRR LWEREAVLVR RQDHTYYQGL FSTADLDSML RNEEVQFGQH LDAARYINGR R Highest antigen sequence identity to the following orthologs - mouse 61%, rat 66%.

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen NO66
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RIOX1
Gene Accession No. Q9H6W3
Gene Alias 2410016O06Rik; 60S ribosomal protein L8 histidine hydroxylase; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; C14orf169; chromosome 14 open reading frame 169; FLJ21802; histone lysine demethylase NO66; hsNO66; lysine-specific demethylase NO66; Mapjd; MNCb-7109; myc associated protein with JmjC domain; MYC-associated protein with JmjC domain; NO66; nucleolar protein 66; RGD1307704; Ribosomal oxygenase 1; Ribosomal oxygenase NO66; RIKEN cDNA 2410016O06 gene; Riox1; ROX; similar to RIKEN cDNA 2410016O06; up-regulated in lung cancer 2; URLC2
Gene Symbols RIOX1
Host Species Rabbit
Immunogen Recombinant Human NO66. Recombinant protein control fragment (Product #RP-105694).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79697
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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