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Invitrogen™ Norepinephrine Transporter Monoclonal Antibody (CL3063)
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Catalog No. PIMA524647
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100 μL
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PIMA524647 100 μL
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Catalog No. PIMA524647 Supplier Invitrogen™ Supplier No. MA524647
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Description

Mouse Monoclonal Antibody

Immunogen sequence: SLYYLFSSFT LNLPWTDCGH TWNSPNCTDP KLLNGSVLGN HTKYSKYKFT PAAEFYERGV LHLHESSGIH DI Binds to an epitope located within the peptide sequence HTKYSKYKFTPAAEF as determined by overlapping synthetic peptides. Highest antigen sequence indentity to the following orthologs: Rat - 93%, Mouse - 93%.

Norepinephrine Transporter [NET, or noradrenaline transporter (NAT)] is a monoamine transporter that transports the neurotransmitter noradrenaline from the synapse back to its vesicles for storage until later use. It also appears to transport the neurotransmitter dopamine in the same way, but to a lesser degree. Studies have shown a decrease in NET levels in the locus coeruleus in patients diagnosed with major depression. Cocaine, amphetamines and many therapeutic antidepressants, such as the SNRIs (serotonin-norepinephrine reuptake inhibitors) and the tricyclic antidepressants (TCAs) act to raise noradrenaline. Furthermore, deficits in the NET gene have been associated with ADHD.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Norepinephrine Transporter
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone CL3063
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC6A2
Gene Accession No. O55192, P23975
Gene Alias NaCl-dependent norepinephrine transporter; NAT1; NE transporter; NET; NE-T; NET1; neurotransmitter transporter; neurotransmitter transporter, noradrenal; NORADR; noradrenaline; noradrenaline transporter; norepinephrine transporter; Slc6a2; SLC6A5; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter), member 2; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; solute carrier family 6 member 2; solute carrier family 6 member 5; transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Symbols SLC6A2
Host Species Mouse
Immunogen Recombinant protein fragment of Human SLC6A2 (Product #RP-102393)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20538, 6530, 83511
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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