Invitrogen™ NOTCH1 Monoclonal Antibody (A6)

Catalog No.	Quantity
PIMA191405	500 μL

Catalog No. PIMA191405 Supplier Invitrogen™ Supplier No. MA191405

Description

Mouse Monoclonal Antibody

MA1-91405 has been successfully used in flow cytometry and immunohistochemistry (paraffin tissue) applications. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 - 20 min followed by cooling at room temperature for 20 min. A suggested positive control for this product is pancreas.

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Specifications

• Antigen: NOTCH1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: A6
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4
• Gene: Notch1
• Gene Accession No.: P46531, Q01705
• Gene Alias: 9930111A19Rik; AOS5; AOVD1; Drosophila Notch homolog 1 (controlling the the ectodermal and neural cell fate in Drosophila); hN1; lin-12; major type A protein; Mis6; Motch; Motch A; mT14; N1; neurogenic locus notch homolog protein 1; NEXT; NICD; NOTCH; notch 1; Notch 1 extracellular truncation; Notch 1 intracellular domain; Notch gene homolog 1; Notch homolog 1, translocation-associated; notch receptor 1; Notch1; p300; RP23-306D20.12; RP23-306D20.12-001; Tan1; Translocation-associated notch protein TAN-1; transmembrane receptor Notch1
• Gene Symbols: Notch1
• Host Species: Mouse
• Immunogen: Recombinant protein encoding the ligand binding region of human Notch 1.
• Purification Method: Protein A
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 18128, 4851
• Target Species: Human, Mouse
• Content And Storage: 4°C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b