NOTCH1 Monoclonal Antibody (OTI2E7), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA808308

Catalog No. 50-168-2041

Description

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Specifications

• Antigen: NOTCH1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: NOTCH1
• Gene Alias: AOS5, AOVD1, TAN1, hN1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4851
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Clone: OTI2E7
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P46531
• Gene Symbols: NOTCH1
• Immunogen: Human recombit protein fragment corresponding to amino acids 2280-2556 of human NOTCH1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1