Invitrogen™ NOTCH2NL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121738

Catalog No. PIPA5121738

Description

NOTCH2NL Polyclonal Antibody for Western Blot, IHC (P)

Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation. [UniProt].

Specifications

• Antigen: NOTCH2NL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOTCH2NL
• Gene Alias: N2N; notch 2 N-terminal like; Notch homolog 2 N-terminal like protein; notch homolog 2 N-terminal-like protein; Notch homolog 2 N-terminal-like protein A; Notch homolog 2 N-terminal-like protein C; NOTCH2NL; NOTCH2NLA; NOTCH2NLC
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 388677
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: Q7Z3S9
• Gene Symbols: NOTCH2NL
• Immunogen: Recombinant protein Notch2 N-Terminal Like Protein.
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Bovine, Human
• Product Type: Antibody
• Isotype: IgG